Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines.
نویسندگان
چکیده
A short and efficient synthesis of 4-aminomethyl-4-fluoropiperidines and 3-aminomethyl-3-fluoropyrrolidines is described. These fluorinated azaheterocycles are of specific interest as bifunctional building blocks for fluorinated pharmaceutical compounds. The key step of the synthetic pathway involves the regioselective bromofluorination of N-Boc-4-methylenepiperidine and 3-methylenepyrrolidine using Et(3)N.3HF and NBS.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 8 11 شماره
صفحات -
تاریخ انتشار 2010